Operating a roll-to-roll coating operation in a clean room presents a unique set of challenges above and beyond the normal rigor needed for precision web coating. In this presentation, the additional steps needed in fluid preparation and filtration will be discussed. Base cleaning considerations will be presented, as will testing procedures for ensuring air cleanliness. Control of static in coating of polymer webs will be delineated. Finally, attention to cleaning procedures for this type of coating operation will be described.