Production of OLED display and OLED lighting modules is currently a vacuum based sheet type small molecule evaporation process. OLED manufacturing have been recently transferred from rigid glass to flexible substrates and first products are commercially available. In general, such flexible substrates are bonded on a glass carrier and will be peeled off after the OLED integration process from the glass carrier. An opportunity for OLED production on flexible substrates is to consider cost effective roll-to-roll fabrication with high throughput for mass market applications. Since 2009 a roll-to-roll vacuum based OLED process line have been brought into operation at Fraunhofer FEP to develop reliable OLED process technologies to cover the complete manufacturing chain. Within the European PI-Scale initiative a goal is to establish pilot production concepts of flexible OLED devices with open access concepts for end-users. The main focus is to develop the OLED market and push business opportunities along the complete value chain. The paper will outline a roll-to-roll OLED pilot production perspective based on vacuum technology on different types of flexible substrates supported by the European PI-Scale project.